An interesting case of anemia with jaundice

Hemoglobinopathies are haematalogical disorders that afflict millions of individuals worldwide. HbE is a hemoglobinvariation caused by a mutation in the ? globin gene that results in the substitution of glutamic acid for lysine at position 26 of the ? globin gene. Hemoglobin (Hb) synthesis abnormalities are among the most prevalent inherited disorders. They can be quantitative (thalassemia syndrome) or qualitative (variant HbS). Hemoglobin E (HbE) is the second most common hemoglobin variation after hemoglobin S (HbS).